Metabolism-associated protein network constructing and host-directed anti-influenza drug repurposing.

ABSTRACT: Host-directed antivirals offer a promising strategy for addressing the challenge of viral resistance. Virus-host interactions often trigger stage-specific metabolic reprogramming in the host, and the causal links between these interactions and virus-induced metabolic changes provide valuable insights for identifying host targets. In this study, we present a workflow for repurposing host-directed antivirals using virus-induced protein networks. These networks capture the dynamic progression of viral infection by integrating host proteins directly interacting with the virus and enzymes associated with significantly altered metabolic fluxes, identified through dual-species genome-scale metabolic models. This approach reveals numerous hub nodes as potential host targets. As a case study, 50 ap

SUBMITTER: Tang H 

PROVIDER: S-EPMC12048005 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature