A bioactive hydrogel patch accelerates revascularization in ischemic lesions for tissue repair.

ABSTRACT:

Background

Magnesium ions play crucial roles in maintaining cellular functions. Research has shown that Mg²⁺ can promote angiogenesis, indicating its potential for treating cardiovascular ischemic diseases. However, conventional intravenous or oral administration of Mg²⁺ presents several challenges, including the risk of systemic side effects, diminished bioavailability, and a lack of targeted delivery mechanisms. In this study, we designed an Mg²⁺-releasing adhesive tissue patch (MgAP) that enables the dural release of Mg²⁺ ions.

Methods

A novel MgAP was developed on the basis of ionic crosslinking. Fourier transform infrared spectroscopy confirmed the chemical structure, whereas rheological analysis demonstrated stable mechanical

SUBMITTER: Liu Z 

PROVIDER: S-EPMC12048007 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature