Characterizing the spatial patterns and determinants of cerebrospinal fluid pseudorandom flow in the human brain with low b-value diffusion MRI.

ABSTRACT: The circulation of cerebrospinal fluid (CSF) is essential for maintaining brain homeostasis and clearance, and impairments in its flow can lead to various brain disorders. Recent studies have shown that CSF effective motility can be interrogated using low b-value diffusion magnetic resonance imaging (low-b dMRI). Nevertheless, the spatial organization of intracranial CSF flow dynamics remains largely elusive. Here, we developed a whole-brain voxel-based analysis framework, termed CSF pseudo-diffusion spatial statistics ( CΨSS ), to examine CSF mean pseudo-diffusivity (MΨ) , a measure of CSF flow magnitude derived from low-b dMRI. We showed that intracranial CSF MΨ demonstrates characteristic covariance patterns by employing seed-based correlation analysis. Next, we applied non-negative mat

SUBMITTER: Nazeri A 

PROVIDER: S-EPMC12048033 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature