Colour changes in the feet: a sign of autonomic symptoms in systemic sclerosis.

ABSTRACT:

Objectives

Patients with autonomic dysfunction, or dysautonomia, often report discolouration of their dependent extremities, which is thought to be from venous pooling or acrocyanosis. A subset of patients with SSc are affected by dysautonomia but may be challenging to identify. We sought to determine whether patients with SSc who report discolouration in their feet have a higher burden of autonomic symptoms, including orthostatic, gastrointestinal (GI), urinary, secretomotor and pupillomotor.

Methods

167 patients with SSc completed the Composite Autonomic Symptom Score (COMPASS)-31 survey, which queries whether the patient experiences discolouration of the feet or hands. We compared the COMPASS-31 subdomain scores between SSc patients with and without foot discolouration. S

SUBMITTER: Adler BL 

PROVIDER: S-EPMC12048065 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature