Soluble urine activated leukocyte cell adhesion molecule is a strong predictor of lupus nephritis.

ABSTRACT:

Objectives

To evaluate urinary activated leucocyte cell adhesion molecule (ALCAM) and CD6 as predictors of LN progression or disease resolution across a 1-year study.

Methods

Serum and urine samples from biopsy proven LN subjects (n = 122) were prospectively collected over the course of a year at 3- or 6-month intervals (weeks 0, 12, 26 and 52) across multiple study sites and assessed for soluble ALCAM and CD6 levels. Urine creatinine from the same urine sample was used to normalize the levels of urinary ALCAM and urinary CD6. Measured levels of serum and urine ALCAM and CD6 were then analysed against disease metrics cross-sectionally and longitudinally.

Results

Cross-sectional analysis at baseline revealed that urinary ALCAM significantly correlated with urine protei

SUBMITTER: Chu D 

PROVIDER: S-EPMC12048083 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature