Solid phase extraction chromatography-based radiochemical isolation of cyclotron-produced ⁵¹Mn from enriched ⁵⁴Fe targets.

ABSTRACT: We report DGA extraction chromatography isolation of ⁵¹Mn from isotopically enriched ⁵⁴Fe. The method has been studied in semi-automated and automated realizations. The former achieves a decay corrected radiochemical yield of 78 ± 1 % (n = 3) and a separation factor of (1.0 ± 0.8) x 10⁵ (n = 3). With GE HealthCare's Solid Target Platform (STP) and FASTlab the latter, fully automated method achieves a decay corrected radiochemical yield of 87 ± 1 % (n = 3) and a separation factor of (2.7 ± 0.9) x 10⁴ (n = 3). Both setups efficiently isolate cyclotron-produced ⁵¹MnCl₂ suitable for human administration as determined by developed Chemistry, Manufacturing, and Controls (CMC) acceptance criteria, and support exploration of ⁵¹

SUBMITTER: Barrett KE 

PROVIDER: S-EPMC12048252 | biostudies-literature | 2025 Mar-Apr

REPOSITORIES: biostudies-literature