Absolute lymphocyte count trajectory predicts clinical outcome in severely injured patients.

ABSTRACT:

Purpose

Lymphopenia is associated with adverse clinical outcome in trauma, but no immunomonitoring method is established to identify patients at risk. Absolute lymphocyte count (ALC) represents a promising biomarker and may support clinical decision-making in the intensive care unit (ICU). This study examined the temporal patterns of ALC in severely injured patients and their correlation with clinical outcomes.

Methods

38 severely injured patients with an Injury Severity Score (ISS) of 18 and greater were enrolled. Blood samples were collected on admission and after 8, 24 and 48 h and 5 and 10 days. 38 healthy volunteers served as controls. Patients were classified into four groups after 48 h based on their dynamic ALC: persistent lymphopenia (PL), rapidly decreasing (RD), s

SUBMITTER: Reichardt LM 

PROVIDER: S-EPMC12048453 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature