Brain connectomics markers for response prediction to transcranial magnetic stimulation in cocaine use disorder.

ABSTRACT: Cocaine use disorder (CUD) is a worldwide health problem with limited effective treatment options. The therapeutic potential of repetitive transcranial magnetic stimulation (rTMS) is gaining more attention following evidence of its role on craving reduction in CUD. However, the heterogeneity of results underscores a pressing need for biomarkers of treatment outcome. We asked whether brain connectomics together with clinical assessments can predict response to add-on rTMS therapy for CUD better than solely conventional clinical assessments. Forty-four randomly assigned CUD patients underwent the 2-week double-blind acute phase [Sham (n = 20, 2f./18m.) and Active (n = 24, 4f./20m.)], in which they received 2 daily sessions of rTMS on the left dorsolateral prefrontal cortex. Subsequently, 19

SUBMITTER: Ghazi N 

PROVIDER: S-EPMC12048481 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature