Integrating metagenomics and metabolomics to study the gut microbiome and host relationships in sports across different energy systems.

ABSTRACT: The gut microbiome plays a critical role in modulating host metabolism, influencing energy production, nutrient utilization, and overall physiological adaptation. In athletes, these microbial functions may be further specialized to meet the unique metabolic demands of different sports disciplines. This study explored the role of the gut microbiome in modulating host metabolism among Colombian athletes by comparing elite weightlifters (n = 16) and cyclists (n = 13) through integrative omics analysis. Fecal and plasma samples collected one month before an international event underwent metagenomic, metabolomic, and lipidomic profiling. Metagenomic analysis revealed significant microbial pathways, including L-arginine biosynthesis III and fatty acid biosynthesis initiation. Key metabolic pathw

SUBMITTER: Aya V 

PROVIDER: S-EPMC12048592 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature