Sex-specific hypothalamic neural projection activity drives caregiving in mice.

ABSTRACT: Infant care is critical for survival and healthy development. In laboratory mice, unmated males and females display infant-directed behavior ranging from neglect and aggression to alloparental care. Previous research suggests that excitatory neurons in the perifornical area of the hypothalamus (PeFA) mediate pup-directed aggression. Because medial preoptic area galanin-expressing (MPOA^Gal) neurons are indispensable for caregiving, we hypothesized that inhibitory MPOA^Gal projections to PeFA prevent pup-directed aggression. We found that MPOA^Gal→PeFA projection activity increased during pup approach in both sexes, and alloparental females showed increased projection activity during pup grooming compared to males. Anatomical differences did not explain this di

SUBMITTER: Carta I 

PROVIDER: S-EPMC12048593 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature