Fecal transplantation from humans with obesity to mice drives a selective microbial signature without impacting behavioral and metabolic health.

ABSTRACT: Obesity is associated with alterations in the gut microbiome that may contribute to metabolic and mental health disturbances. Fecal microbiota transplantation (FMT) from humans to mice is a model proposed to study human microbiota-associated disorders. In this study, we investigated whether gut microbiota from human donors with obesity could affect behavior and metabolomic profiles of mice. Stools from donors with obesity and from lean donors were inoculated to antibiotic-pretreated mice fed a standard low-fat diet throughout the experiment. Obese-recipient mice exhibited a lower bacterial alpha-diversity and limited changes in specific taxa (e.g., an increase in Eubacterium) but were similar to lean-recipient mice in terms of dietary intake, body weight, fat mass, anxiety/depression-like

SUBMITTER: Neyrinck AM 

PROVIDER: S-EPMC12048625 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature