T-cell-derived IFN-γ suppresses T follicular helper cell differentiation and antibody responses.

ABSTRACT: CD4⁺ T cells play a critical role in antiviral humoral and cellular immune responses. We have previously reported that subcutaneous lymphocytic choriomeningitis virus (s.c. LCMV) infection is characterized by a stark compartmentalization of CD4⁺ T cells, leading to strong T_H1 cell polarization but virtually absent T follicular helper (T_FH) cells, key drivers of humoral immunity. Here, we investigate the mechanisms responsible for this impaired T_FH differentiation. We show that T-bet⁺ cells induced by LCMV infection encompass a T_H1 cell subset expressing granzyme B (GzmB), and a Tcf-1⁺ cell subset that retains the potential for T_FH differentiation without expressing mature T_FH marke

SUBMITTER: Sala E 

PROVIDER: S-EPMC12048687 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature