Exploring ribosome biogenesis in lung adenocarcinoma to advance prognostic methods and immunotherapy strategies.

ABSTRACT:

Background

Lung adenocarcinoma (LUAD) presents a considerable danger to human health and has evolved into a major public health concern. Ribosome biogenesis (RiboSis) is a critical process for synthesizing ribosomes, closely associated with cancer initiation, progression, and treatment resistance, potentially serving as a target for future cancer therapies.

Methods

Utilizing single-cell RNA sequencing (scRNA-seq) technology, a single-cell atlas of LUAD was delineated, focusing on the analysis of T cell subpopulations. Cells were scored based on the expression patterns of 331 genes associated with RiboSis across different cell types, and monocle2 was employed to analyze the developmental trajectory of CD4⁺ T cells. Employing various machine learning algorithms, a r

SUBMITTER: Song Z 

PROVIDER: S-EPMC12048935 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature