Bioinformatic exploration of RiPP biosynthetic gene clusters in lichens.

ABSTRACT:

Background

Ribosomally synthesized and posttranslationally modified peptides (RiPPs) represent a relatively recent addition to the biosynthetic gene cluster (BGC) repertoire of fungi. These BGCs are primarily involved in toxins production and defense-related functions and resulting metabolites also have a significant therapeutic potential. While only a limited number of fungal RiPPs, primarily from a few model fungi, have been characterized, genome mining approaches show that RiPP BGCs are nearly ubiquitous across the fungal kingdom. However, the RiPP biosynthetic landscape of fungi involved in intricate relationship as symbiosis, such as lichen-forming fungi (LFF), remains unexplored.

Results

This study presents the first comprehensive survey of RiPP BGCs across 111 LFF gen

SUBMITTER: Pasinato A 

PROVIDER: S-EPMC12048977 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature