Limited cell-autonomous anticancer mechanisms in long-lived bats.

ABSTRACT: Several bat species live >20-40 years, suggesting that they possess efficient anti-aging and anti-cancer defenses. Here we investigate the requirements for malignant transformation in primary fibroblasts from four bat species Myotis lucifugus, Eptesicus fuscus, Eonycteris spelaea, and Artibeus jamaicensis - spanning the bat evolutionary tree and including the longest-lived genera. We show that bat fibroblasts do not undergo replicative senescence, express active telomerase, and show attenuated SIPs with dampened secretory phenotype. Unexpectedly, unlike other long-lived mammals, bat fibroblasts are readily transformed by two oncogenic "hits": inactivation of p53 or pRb and activation of HRAS^G12V. Bat fibroblasts exhibit increased TP53 and MDM2 transcripts and elevated p53-depend

SUBMITTER: Athar F 

PROVIDER: S-EPMC12049446 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature