Hippocampal-entorhinal cognitive maps and cortical motor system represent action plans and their outcomes.

ABSTRACT: Efficiently interacting with the environment requires weighing and selecting among multiple alternative actions based on their associated outcomes. However, the neural mechanisms underlying these processes are still debated. We show that forming relations between arbitrary action-outcome associations involve building a cognitive map. Using an immersive virtual reality paradigm, participants learned 2D abstract motor action-outcome associations and later compared action combinations while their brain activity was monitored with fMRI. We observe a hexadirectional modulation of the activity in entorhinal cortex while participants compared different action plans. Furthermore, hippocampal activity scales with the 2D similarity between outcomes of these action plans. Conversely, the supplementar

SUBMITTER: Barnaveli I 

PROVIDER: S-EPMC12049502 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature