The biomarker potential of circPOLD1 and its binding protein YBX1 in cervical carcinogenesis.

ABSTRACT:

Background

Cervical cancer progresses through distinct precancerous stages, making early screening and intervention crucial for prevention. However, conventional screening modalities, such as cytology and HPV testing, face challenges related to sensitivity, specificity, and resource dependency. Circular RNAs (circRNAs), owing to their high stability and tissue-specific expression, have emerged as promising biomarkers, though their role in cervical carcinogenesis remains underexplored. In particular, the clinical utility of circRNAs for optimizing cervical cancer screening and early diagnosis has yet to be established. This study aimed to investigate the dynamic expression profiles of circRNAs across various stages of cervical cancer progression and identify potential biomarkers to

SUBMITTER: Zhao L 

PROVIDER: S-EPMC12049807 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature