RAC2 inhibition enhances tumor sensitivity to NK cell-mediated cytotoxicity.

ABSTRACT:

Background

Natural killer (NK) cells are recognized for their ability to kill tumor cells for tumor control, but tumor cells often develop resistance to evade NK cell-mediated cytotoxicity. Identification of molecular mechanisms by which tumor cells evade from NK cell-mediated killing may offer novel therapeutic strategies for potentiating NK-based cancer immunotherapy.

Methods

An in vitro tumor-NK cell co-culture system was employed to identify the most significantly altered genes in tumor cells following NK cell interaction. The cell death rate of tumor cells by NK cell exposure was quantified using flow cytometry. EL4 and HCT116 tumor models in C57BL/6, BALB/c-nu, and NOD/SCID mice were used for evaluating tumor growth differences induced by Rac2 knockdown or knock

SUBMITTER: Guo H 

PROVIDER: S-EPMC12049936 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature