Genetic architecture and socio-environmental risk factors for major depressive disorder in Nepal.

ABSTRACT:

Background

Major depressive disorder (MDD) is the leading cause of disability globally, with moderate heritability and well-established socio-environmental risk factors. Genetic studies have been mostly restricted to European settings, with polygenic scores (PGS) demonstrating low portability across diverse global populations.

Methods

This study examines genetic architecture, polygenic prediction, and socio-environmental correlates of MDD in a family-based sample of 10 032 individuals from Nepal with array genotyping data. We used genome-based restricted maximum likelihood to estimate heritability, applied S-LDXR to estimate the cross-ancestry genetic correlation between Nepalese and European samples, and modeled PGS trained on a GWAS meta-analysis of European and East Asian

SUBMITTER: Choi KW 

PROVIDER: S-EPMC12050005 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature