SOCS1 Protects Acute Myeloid Leukemia against Allogeneic T Cell-Mediated Cytotoxicity.

ABSTRACT:

Significance

Our investigation of the SOCS1 pathway in AML and T-cell interactions provides insights into potential mechanisms of resistance of AML to allogeneic hematopoietic stem cell transplantation and demonstrates the potential of targeting SOCS1 and its downstream mediators to enhance antileukemic T-cell activity. See related commentary by Fry, p. 157.

SUBMITTER: Tin E 

PROVIDER: S-EPMC12050964 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature