Risks of peri- and postoperative complications with glucagon-like peptide-1 receptor agonists.

ABSTRACT:

Aim

To assess whether adults with diabetes on oral hypoglycaemic agents undergoing general endotracheal anaesthesia during nine common surgical procedures who are glucagon-like peptide-1 receptor agonist (GLP1-RA) users, compared with non-users, are at increased risk of six peri- and post-procedure complications.

Materials and methods

A retrospective observational cohort analysis of over 130 million deidentified US adults with diabetes (defined as being on oral hypoglycaemic agents) from a nationally representative electronic health dataset between 1 January 2015 and 1 April 2023 was analysed. Cohorts were matched by high-dimensionality propensity scoring. We compared the odds of six peri- and postoperative complications in GLP1-RA users and non-users. A sensitivity analysis

SUBMITTER: Klonoff DC 

PROVIDER: S-EPMC12051400 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature