Spatial distribution of cytoskeleton-mediated feedback controls cell polarization: a computational study.

ABSTRACT: In the social amoeba Dictyostelium, cell motility is regulated through a signal transduction excitable network that interfaces with the cytoskeleton to control actin polymerization patterns. In turn, the cytoskeleton influences the signaling machinery via several feedback loops, but the nature and function of this feedback remain poorly understood. In this study, we use computational models to discern the essential role of complementary positive and negative feedback loops in polarizing cells. We contrast two potential mechanisms for the negative feedback: local inhibition and global inhibition. Our results indicate that both mechanisms can stabilize the leading edge and inhibit actin polymerization in other sites, preventing multipolarity. While some experimental perturbations alig

SUBMITTER: Banerjee P 

PROVIDER: S-EPMC12051494 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature