CXCL13 suppresses liver regeneration through the negative regulation of HGF signaling.

ABSTRACT: Insufficient liver regeneration increases the risk of postoperative liver failure following liver transplantation or partial hepatectomy (PHx). Numerous growth factors and cytokines are related to liver regeneration; however, the underlying mechanisms have not been fully elucidated. In this study, CXCL13 was identified as a key factor delaying liver regeneration after PHx. We observed that CXCL13 expression was upregulated in PHx mice and patients following liver resection. CXCL13 deficiency accelerated liver regeneration, whereas these effects were abolished by recombinant murine CXCL13 administration. Moreover, proteomics analyses indicated that HGF levels in the serum after PHx were significantly greater in Cxcl13^-/- mice than in WT mice. Further analysis revealed that CXCL13

SUBMITTER: Zhao Q 

PROVIDER: S-EPMC12052986 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature