Oligoadenylate synthetase-like aggravated Newcastle disease virus-induced necroptosis in glioma cells.

ABSTRACT:

Background

Newcastle disease virus (NDV) has emerged as a tumor-lysing agent in a variety of cancers. Previous studies have shown that NDV has cytolytic activity in gliomas; however, the underlying mechanisms have not been fully elucidated.

Methods

Comparing the glioma cells LN229 controlled group with the infected group of NDV rLa Sota-GFP strain, we strive to observe the changes in the genome and protein levels as well as the activation of the signalling pathways before and after the infection at the cellular level and at the level of the genes in the transcriptome, to study the molecular mechanism of necroptosis of the NDV-infected lethal LN229.

Results

We found that NDV infection which inhibited glioma cells LN229 proliferation and promoted apoptosis in a dose-dep

SUBMITTER: Yu Z 

PROVIDER: S-EPMC12053153 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature