D-enantiomeric antibiofilm peptides effective against anaerobic <i>Cutibacterium acnes</i> biofilm.

ABSTRACT: The emergence of antibiotic resistance, biofilm formation, and internalization by host cells contribute to a high risk of chronic infections, highlighting the necessity to develop novel therapeutic strategies. Identification of natural host defense peptides (HDPs) with promising antimicrobial and antibiofilm activities led to the development of synthetic peptides with broad-spectrum efficacy. However, few studies have examined their effect on anaerobic bacterial species. This study aimed to test the effect of synthetic HDPs on Cutibacterium acnes, an anaerobe species involved in 10% of prosthesis joint infections (PJI). A preliminary screen identified three peptides (DJK5, AB009-D, and AB101-D) with promising activity against four C. acnes strains (two of which were isolated

SUBMITTER: Varin-Simon J 

PROVIDER: S-EPMC12053997 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature