Gut microbiota's role in the enhancement of type 2 diabetes treatment by a traditional Chinese herbal formula compared to metformin.

ABSTRACT: Type 2 diabetes mellitus (T2DM) is a rapidly increasing metabolic disorder that poses a significant threat to global public health. Recent evidence suggests that targeting the gut microbiota through dietary and pharmaceutical interventions can effectively manage T2DM. In this study, we developed a novel Chinese herbal formula, CCM, specifically for T2DM, composed of Coptis rhizoma, Cinnamomi cortex, and Mume fructus. To evaluate CCM's efficacy and explore its underlying mechanisms, particularly the role of the gut microbiota, diabetic C57/db/db mice were administered different doses of CCM (low, medium, high) for 4 weeks, with normal C57 mice as healthy controls and metformin as a positive control. Comprehensive clinical indicators of T2DM were measured before and afte

SUBMITTER: Xia C 

PROVIDER: S-EPMC12054121 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature