Recent emergence of cephalosporin-resistant <i>Salmonella</i> Typhi in India due to the endemic clone acquiring IncFIB(K) plasmid encoding <i>bla</i><sub>CTX-M-15</sub> gene.
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ABSTRACT: The emergence and spread of Salmonella Typhi (S. Typhi) resistant to third-generation cephalosporins is a serious global health concern. In this study, we genomically characterized 142 cephalosporin-resistant S. Typhi strains isolated from India. Comparative genome analysis revealed the emergence of a new clone of ceftriaxone-resistant S. Typhi harboring three plasmids of the incompatibility groups IncFIB(K), IncX1, and IncFIB(pHCM2). Among these, the IncFIB(K) plasmid confers resistance to third-generation cephalosporins through the blaCTX-M-15 gene, along with other resistance determinants such as aph(3"), aph(6'), sul2, dfrA14, qnrS, and tet(A). Phylogenetic analysis showed that the isolates from Guj
SUBMITTER: Thirumoorthy TP
PROVIDER: S-EPMC12054180 | biostudies-literature | 2025 Apr
REPOSITORIES: biostudies-literature
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