Molecular mechanisms explaining sex-specific functional connectivity changes in chronic insomnia disorder.

ABSTRACT:

Background

This study investigates the hypothesis that chronic insomnia disorder (CID) is characterized by sex-specific changes in resting-state functional connectivity (rsFC), with certain molecular mechanisms potentially influencing CID's pathophysiology by altering rsFC in relevant networks.

Methods

Utilizing a resting-state functional magnetic resonance imaging (fMRI) dataset of 395 participants, including 199 CID patients and 196 healthy controls, we examined sex-specific rsFC effects, particularly in the default mode network (DMN) and five insomnia-genetically vulnerable regions of interest (ROIs). By integrating gene expression data from the Allen Human Brain Atlas, we identified genes linked to these sex-specific rsFC alterations and conducted enrichment analysis to

SUBMITTER: Yu L 

PROVIDER: S-EPMC12054257 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature