Pathogen growth and virulence dynamics drive the host evolution against coinfections.

ABSTRACT: The occurrence of coinfections, where hosts are simultaneously infected by multiple pathogens, is widespread in nature and has significant negative impacts on global health. In humans, over one-sixth of the world's population is affected by coinfections, contributing to several diseases. However, despite the broad ecological relevance and impact on global health, most biomedical research has focused on understanding interactions between a single host and a single pathogen. The extent to which coinfections could impact host adaptation and immune system evolution, particularly in comparison to infections by single pathogens, thus remains largely unknown. Also, what roles do individual pathogen species play in this evolutionary process? To address these questions, in this study, we combined t

SUBMITTER: Seal S 

PROVIDER: S-EPMC12054814 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature