Infrared light stimulates the cochlea through a mechanical displacement detected and amplified by hair cells.

ABSTRACT: Although cochlear implants (CI) are the standard of care for profound sensorineural hearing loss they are technically constrained by the tendency of electrical current to spread within the fluid-filled chambers of the cochlea. This limits the resolution of individual electrodes and patients' perceptions of complex sounds. Infrared irradiation has been proposed as an alternative to electrical stimulation because it can elicit auditory responses while being spatially constrained, theoretically promising higher-fidelity hearing for the deaf. However, conflicting reports locate the site of infrared excitation at spiral ganglia neurons or hair cells. We use a combination of genetic, pharmacological, optical, and electrophysiological tools to determine the site of action of infrared irradiation.

SUBMITTER: Azimzadeh JB 

PROVIDER: S-EPMC12054842 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature