Mammary gland multi-omics data reveals new genetic insights into milk production traits in dairy cattle.

ABSTRACT: Although many sequence variants have been discovered in cattle, deciphering the relationship between genome and phenome remains a significant challenge. In this study, we identified functional classes, including mammary-specific genes, lactation-associated genes, novel long non-coding RNAs, miRNAs, RNA editing sites, DNA methylation, histone modifications, and expression quantitative trait loci. We estimated their contributions to genetic variance for milk production traits using 3 million variants in 23,566 Holstein bulls. Sequence variants in the 5'-UTR, synonymous, and splicing regions disproportionately contributed to genetic variance of milk production traits compared to other genomic regions. Genes specifically expressed in the mammary gland, particularly those active in lactating ti

SUBMITTER: Cai W 

PROVIDER: S-EPMC12054919 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature