Neuronal dynamics direct cerebrospinal fluid perfusion and brain clearance.

ABSTRACT: The accumulation of metabolic waste is a leading cause of numerous neurological disorders, yet we still have only limited knowledge of how the brain performs self-cleansing. Here we demonstrate that neural networks synchronize individual action potentials to create large-amplitude, rhythmic and self-perpetuating ionic waves in the interstitial fluid of the brain. These waves are a plausible mechanism to explain the correlated potentiation of the glymphatic flow^1,2 through the brain parenchyma. Chemogenetic flattening of these high-energy ionic waves largely impeded cerebrospinal fluid infiltration into and clearance of molecules from the brain parenchyma. Notably, synthesized waves generated through transcranial optogenetic stimulation substantially potentiated cerebrospinal flu

SUBMITTER: Jiang-Xie LF 

PROVIDER: S-EPMC12054998 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature