The long-term associations of perinatal obesogenic environment with offspring biological aging.

ABSTRACT: Biological age (BA), reflecting aging-related health decline beyond chronological age, varies among individuals. While previous research explored associations of maternal pregnancy-related body size with offspring health outcomes, its implications for BA in young adults remain unclear. Utilizing longitudinal data of 1148 mother-offspring pairs from the Jerusalem Perinatal Study, we analyzed associations of maternal prepregnancy BMI and gestational weight gain (GWG) with offspring using the Klemera-Doubal method (KDM)-based BA at age 32 and potential familial life-course underlying mechanisms. Maternal pregnancy-related body size, adjusted for sociodemographic/lifestyle factors was associated with offspring BA (βmaternal prepregnancy BMI = 0.183; 95% CI, 0.098-0.267; βGWG = 0.093; 95% CI, 0

SUBMITTER: Shapiro I 

PROVIDER: S-EPMC12055458 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature