Nosocomial lower respiratory tract infections in patients with immunosuppression: a cohort study.

ABSTRACT:

Background

This post-hoc analysis of a multinational, multicenter study aimed to describe and compare clinical characteristics, microbiology, and outcomes between immunosuppressed and non-immunosuppressed patients with nosocomial lower respiratory tract infections (nLRTI). The study utilized data from the European Network for ICU-related Respiratory Infections, including 1,060 adult ICU patients diagnosed with nLRTI. Descriptive statistics were used to compare baseline characteristics and pathogen distribution between groups. A Cox proportional hazards model stratified by immunosuppression status was applied to assess 28-day mortality risk, adjusting for disease severity and key clinical variables.

Results

Immunosuppression was observed in 24.9% (264/1060) of the patients, a

SUBMITTER: Reyes LF 

PROVIDER: S-EPMC12055687 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature