Effect of Treatment with Mucoactive Drugs on COPD Exacerbations During 5 years of Follow-up in the Czech Republic: A Real-World Study.

ABSTRACT:

Introduction

Studies indicate that chronic treatment with mucoactive drugs may reduce COPD exacerbation rates. This real-world, multicenter, prospective, observational study aimed to determine the effect of long-term mucoactive treatment on exacerbations in patients with COPD in the Czech Republic.

Methods

452 adult patients on the Czech Multicenter Research Database of COPD with post-bronchodilator FEV₁ ≤ 60% of predicted value received standard of care and were followed up for 5 years. For the first 24 months, 81 patients received regular thiol-based mucoactive drugs (77 erdosteine, 4 N-acetylcysteine) at the discretion of the treating physician and 371 patients had no mucoactive treatment (control group). Erdosteine was fully reimbursed, and NAC was partially r

SUBMITTER: Zatloukal J 

PROVIDER: S-EPMC12055937 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature