Characterization of a rapid 17β-estradiol-degrading strain, Microbacterium proteolyticum ZJSU01.

ABSTRACT: Estrogens, particularly 17β-estradiol, are prevalent endocrine-disrupting chemicals in aquatic environments, posing risks to ecosystems and human health. Biodegradation is considered one of the most effective and environmentally friendly methods for removing estrogen. In this study, a novel bacterial strain, Microbacterium proteolyticum ZJSU01, was isolated from pig manure. It completely degraded 5 mg/L of 17β-estradiol (E2) within 4 h, as well as its major transformation product, estrone (E1). The strain ZJSU01 displayed strong adaptability to high temperatures (37℃, 42℃) and a broad pH range (6-11), E2 (5 mg/L) could be completely removed by the strain under these conditions. Transformation intermediates were analyzed using UHPLC and HPLC-Q-TOF-MS to identify key metabolites and trace th

SUBMITTER: Chen Y 

PROVIDER: S-EPMC12055944 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature