Integrated bioinformatics, machine learning, and molecular docking reveal crosstalk genes and potential drugs between periodontitis and systemic lupus erythematosus.

ABSTRACT: Evidence indicates a connection between periodontitis (PD) and systemic lupus erythematosus (SLE), though the underlying co-morbid mechanisms remain unclear. This study sought to identify the genetic factors and potential therapeutic agents involved in the interaction between PD and SLE. We employed multi-omics methodologies, encompassing differential expression analysis, weighted gene co-expression network analysis (WGCNA), functional enrichment (GO/KEGG), LASSO regression, diagnostic model construction, protein-protein interaction (PPI) networks, immune infiltration profiling, computational drug prediction, molecular docking, and disease subtyping, to analyze PD and SLE expression datasets from the Gene Expression Omnibus (GEO) database (GSE10334, GSE16134, GSE50772, and GSE81622). Cross

SUBMITTER: Wang J 

PROVIDER: S-EPMC12055969 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature