Phylogenetic divergence of GABA_B receptor signaling in neocortical networks over adult life.

ABSTRACT: Cortical circuit activity is controlled by GABA-mediated inhibition in a spatiotemporally restricted manner. GABA_B receptor (GABA_BR) signalling exerts powerful slow inhibition that controls synaptic, dendritic and neuronal activity. But, how GABA_BRs contribute to circuit-level inhibition over the lifespan of rodents and humans is poorly understood. In this study, we quantitatively determined the functional contribution of GABA_BR signalling to pre- and postsynaptic domains in rat and human cortical principal cells. We find that postsynaptic GABA_BR differentially control pyramidal cell activity within the cortical column as a function of age in rodents, but minimally change over adult life in humans. Presynaptic GABA_BRs exert

SUBMITTER: Wilson MA 

PROVIDER: S-EPMC12056048 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature