Exploring the genetic intersection between obesity-associated genetic variants and insulin sensitivity indices.

ABSTRACT: Insulin sensitivity (IS) is a key determinant of metabolic health and may share genetic factors with obesity-related traits. Previous large-scale genetic studies have identified variants associated with IS as well as obesity related traits like body mass index (BMI) and waist-to-hip ratio (WHR). Notably, many of these associations are shared across traits, indicating a potential genetic overlap. However, the genetic intersection between IS and obesity-related traits remains underexplored. To explore this gap, we investigated associations between six IS indices, including fasting and post-glucose load measures, and genetic variants linked to BMI and WHR to determine their influence on IS and related cardiometabolic traits. To achieve this, we calculated six IS indices using fasting and oral

SUBMITTER: Suleman S 

PROVIDER: S-EPMC12056085 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature