Plasma biomarkers as core mediators in functional network abnormalities: Evidence from a two-cohort study.

ABSTRACT:

Introduction

Researchers have reported an association among amyloid beta (Aβ), tau deposition, and functional networks. Nevertheless, whether plasma biomarkers mediate this process remains unclear.

Methods

Three hundred and forty-eight participants with available plasma biomarkers, Aβ positron emission tomography (PET), and resting-state functional magnetic resonance imaging were obtained from two independent cohorts: SILCODE (n = 147) and ADNI (n = 201). Correlations among plasma biomarkers, functional connectivity, and global standardized uptake value ratio (SUVR) were assessed, and mediating effects were analyzed to explore underlying pathways.

Results

Plasma biomarkers (p-tau181, p-tau217, neurofilament light, glial fibrillary acidic protein, Aβ42/40) demonstrated

SUBMITTER: Wei M 

PROVIDER: S-EPMC12056302 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature