Emotional response to amyloid beta status disclosure among research participants at high dementia risk.

ABSTRACT:

Introduction

Amyloid beta (Aβ) can be detected in vivo years before Alzheimer's disease (AD) symptom onset and, according to recent criteria, is sufficient for a biological diagnosis. This study evaluates emotional responses to Aβ status disclosure in cognitively normal individuals.

Methods

Questionnaires were given before and 6 months after Aβ positron emission tomography results disclosure to assess anxiety and depression related to the possibility of an elevated result, subjective memory complaints, and motivation for risk-reduction behavior.

Results

One hundred ninety-nine cognitively normal adults were included. Non-elevated Aβ status disclosure was associated with reductions in all emotional parameters compared to baseline (p < 0.001). Elevated Aβ disclosure was

SUBMITTER: Golan Shekhtman S 

PROVIDER: S-EPMC12056598 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature