Isolating the effects of HIV infection and HIV exposure on epigenetic profiles in infants using historical data from the Mothers and Infants Cohort Study.

ABSTRACT:

Background

Epigenetics offers insight into the mechanisms by which early life HIV infection and HIV exposure in utero affects offspring health. However, due to the widespread use of antiretroviral therapy (ART) during pregnancy/infancy, contemporary studies are unable to disentangle effects of HIV from ART exposure on epigenetic profiles.

Methods

Using historical specimens collected before widespread use of ART (1985-1991), we compared DNA methylation (DNAm) profiles among infants with perinatally-acquired HIV (PHIV), HIV-exposed but uninfected (HEU), and HIV-unexposed uninfected (HUU). DNAm in peripheral blood mononuclear cells collected at 3 and 12 months of age (36 PHIV, 33 HEU, and 33 HUU) was profiled using the Illumina Infinium MethylationEPIC BeadChip. We tested for d

SUBMITTER: Douglas J 

PROVIDER: S-EPMC12056770 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature