Therapeutic effect of edaravone on osteoarthritis: targeting NRF2 signaling and mitochondrial function.

ABSTRACT:

Background

Osteoarthritis (OA), the most prevalent form of arthritis, is swiftly emerging as a chronic health condition, that poses the primary cause of disability and significant socioeconomic burden. Despite its prevalence, effective therapeutic options for OA remain elusive. This study seeks to explore the therapeutic potential of edaravone (EDA), a FDA-approved free radical scavenger, in the context of OA development and to elucidate its underlying mechanisms.

Methods

In vitro, oxidative stress models were induced by stimulating chondrocytes with t-butylhydroperoxide (TBHP); then, we investigated the influence of EDA on chondrocyte dysfunction, apoptosis, inflammatory responses and mitochondrial function in TBHP-treated chondrocytes, along with the underlying mech

SUBMITTER: Jiang C 

PROVIDER: S-EPMC12056803 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature