T-lymphocytes suppression by CD14⁺ monocytes with high expression of ULK2 in patients with multiple myeloma.

ABSTRACT:

Background

Multiple myeloma (MM), a plasma cell malignancy, remains incurable and is highly prone to relapse. Immunosuppressive cells in the bone marrow environment inhibit endogenous T-lymphocytes activity and reduce the efficacy immunotherapies. Abnormal bone marrow monocytes in MM have been associated with inferior outcomes. This study explored the mechanism of T-lymphocytes suppression by bone marrow CD14⁺ monocytes in MM.

Methods

Single-cell RNA sequence data (GSE124310) derived from MM samples were analyzed. CD14⁺ monocytes from the bone marrow of patients with newly-diagnosed MM were detected, and RNA sequencing was performed. Interactions between CD14⁺ monocytes and T-lymphocytes, as along with the corresponding downstream signaling m

SUBMITTER: Peng F 

PROVIDER: S-EPMC12057009 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature