Allelic variation in a cluster of epsilon glutathione S-transferase genes contributes to DDT and pyrethroid resistance in the major African malaria vector Anopheles funestus.

ABSTRACT:

Background

Insecticide resistance in malaria vectors is a serious challenge to malaria control and elimination. Elucidation of the role of detoxification genes in resistance is necessary to develop targeted strategies to reduce malaria burden. Glutathione S-transferase epsilon clusters (GSTe genes) are upregulated in DDT- and pyrethroid-resistant Anopheles funestus mosquitoes across Africa. However, except for GSTe2, the molecular mechanisms behind this upregulation remain unclear. Here, we established that overexpression and allelic variation of GSTe genes contribute to insecticide resistance in African malaria vector An. funestus s.s.

Methods

Transcriptomic and genomic analyses of GSTe genes were conducted, followed by in silico structural analysis, and functional characte

SUBMITTER: Kouamo MFM 

PROVIDER: S-EPMC12057082 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature