Deleting fis downregulates virulence and effectively protects Pasteurella multocida infection in mice.

ABSTRACT: Pasteurella multocida (P. multocida) is an important pathogen causing various diseases in both domestic and wild animals. The factor for inversion stimulation (Fis) is a nucleoid-associated protein with diverse functions in various bacteria, which positively regulate the transcription of capsular glycosaminoglycan genes in P. multocida. However, the precise mechanistic understanding of how the fis regulate virulence of P. multocida remains largely unknown. In this study, we discovered that fis transcript levels of P. multocida CQ2, serotype A (PmCQ2) were significantly increased in vivo, and showed a positive correlation with the capsule and virulence of P. multocida. To further understand how the fis regulated P. multocida pathogenesis, a homologous recombination strategy was used to gene

SUBMITTER: Wang Z 

PROVIDER: S-EPMC12057170 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature