Associations between psoriasis and risk of 33 cancers: a Mendelian randomization study.

ABSTRACT:

Background

Several observational studies have reported epidemiologic associations between psoriasis and risk of some cancers, but systematic evidence is lacking. Our aim was to comprehensively estimate the association between psoriasis and the risk of 33 common cancers using systematical Mendelian randomization based on genetic data.

Method

Forty-nine independent single-nucleotide polymorphisms (SNPs) significantly associated with psoriasis were extracted as instrumental variables from a large-scale meta-analysis study of genome-wide association study (GWAS) for psoriasis. Outcome GWAS data were obtained from the FinnGen consortium (n = 500,348), UK Biobank (n = 420,531), and other large-scale cancer datasets. The inverse-variance weighted (IVW) was used as the primary metho

SUBMITTER: Liu M 

PROVIDER: S-EPMC12057250 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature