Advances in cancer immunotherapy: historical perspectives, current developments, and future directions.

ABSTRACT: Cancer immunotherapy, encompassing both experimental and standard-of-care therapies, has emerged as a promising approach to harnessing the immune system for tumor suppression. Experimental strategies, including novel immunotherapies and preclinical models, are actively being explored, while established treatments, such as immune checkpoint inhibitors (ICIs), are widely implemented in clinical settings. This comprehensive review examines the historical evolution, underlying mechanisms, and diverse strategies of cancer immunotherapy, highlighting both its clinical applications and ongoing preclinical advancements. The review delves into the essential components of anticancer immunity, including dendritic cell activation, T cell priming, and immune surveillance, while addressing the challenge

SUBMITTER: Zhang M 

PROVIDER: S-EPMC12057291 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature