Revisiting the causal impact of lipid traits on metabolic dysfunction-associated fatty liver disease: Insights from a multidimensional plasma lipid profile.

ABSTRACT:

Aims

Recent advancements in plasma lipidomes genome-wide association studies data have enhanced our understanding of lipid categories, significantly improving risk assessments for metabolic dysfunction-associated fatty liver disease (MAFLD) beyond traditional lipid biomarkers.

Materials and methods

This study utilized Mendelian randomization (MR) to assess the causal relationships between 179 lipid species across 13 subclasses and MAFLD, primarily using the Wald ratio and IVW methods. Corrections were made using false discovery rate (FDR), supplemented by Bayesian colocalization analysis.

Results

Elevated levels of genetically predicted phosphatidylcholine (16:0_16:1) [OR_{Wald ratio} = 2.638, 95% CI 1.557-4.469, P = 3.11 × 10^-4], phosphatidylcholin

SUBMITTER: Xie F 

PROVIDER: S-EPMC12057391 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature