Bacterial Infections in Patients With Severe Alcohol-Associated Hepatitis: Drivers of Organ Failure and Mortality.

ABSTRACT:

Background

Severe alcohol-associated hepatitis (sAH) is a life-threatening condition with limited treatment options. Although corticosteroids offer some benefit in short-term survival, their use remains controversial due to concerns about increased infection risk. Infections are a major cause of mortality in sAH; however, the reasons for this remain unclear.

Methods

A post hoc analysis of the prospective VTL-308 multicentre trial on 151 patients with sAH was performed. Competing-risk models evaluated predictors of infections, the influence of corticosteroids on infection risk, and the impact of infections on the clinical outcomes up to 1 year of follow-up.

Results

Among 151 patients, 90 (59.6%) developed infections. The most frequent were urinary tract (34.4%) and blo

SUBMITTER: Buttler L 

PROVIDER: S-EPMC12057653 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature